Detailed view for TVAG_483890

Basic information

TDR Targets ID: 867243
Trichomonas vaginalis, conserved hypothetical protein
Source Database / ID: 

pI: 5.7838 | Length (AA): 1334 | MW (Da): 149730 | Paralog Number: 4

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01535   PPR repeat

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130315)

Species Accession Gene Product
Caenorhabditis elegans CELE_C27A7.4   Protein CHE-11
Drosophila melanogaster Dmel_CG11838   reduced mechanoreceptor potential A
Echinococcus granulosus EgrG_000374900   intraflagellar transport protein 140
Echinococcus multilocularis EmuJ_000374900   intraflagellar transport protein 140
Homo sapiens ENSG00000187535   intraflagellar transport 140
Leishmania braziliensis LbrM.32.0380   hypothetical protein, conserved
Leishmania donovani LdBPK_320320.1   intraflagellar transport protein 140, putative
Leishmania infantum LinJ.32.0320   hypothetical protein, conserved
Leishmania major LmjF.32.0310   hypothetical protein, conserved
Leishmania mexicana LmxM.31.0310   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_15585   hypothetical protein
Loa Loa (eye worm) LOAG_06991   hypothetical protein
Loa Loa (eye worm) LOAG_12707   hypothetical protein
Mus musculus ENSMUSG00000024169   intraflagellar transport 140
Neospora caninum NCLIV_052170   hypothetical protein, conserved
Onchocerca volvulus OVOC10121  
Onchocerca volvulus OVOC10126  
Schistosoma japonicum Sjp_0108670   IPR008262,Lipase, active site;IPR001680,WD-40 repeat;IPR011046,WD40-like,domain-containing
Schistosoma japonicum Sjp_0101550   Conserved hypothetical protein
Schistosoma mansoni Smp_163250   hypothetical protein
Schmidtea mediterranea mk4.027327.00  
Schmidtea mediterranea mk4.013795.00  
Schmidtea mediterranea mk4.004640.01   Intraflagellar transport protein 140 homolog
Schmidtea mediterranea mk4.004640.00   Intraflagellar transport protein 140 homolog
Trypanosoma brucei gambiense Tbg972.10.17590   hypothetical protein, conserved
Trypanosoma brucei Tb927.10.14470   intraflagellar transport protein 140
Trypanosoma congolense TcIL3000_10_12370   intraflagellar transport protein 140, putative
Trypanosoma cruzi TcCLB.506215.19   intraflagellar transport protein 140, putative
Toxoplasma gondii TGME49_215195   tetratricopeptide repeat-containing protein
Toxoplasma gondii TGME49_215185   hypothetical protein
Trichomonas vaginalis TVAG_083840   conserved hypothetical protein
Trichomonas vaginalis TVAG_404040   conserved hypothetical protein
Trichomonas vaginalis TVAG_003730   conserved hypothetical protein
Trichomonas vaginalis TVAG_483890   conserved hypothetical protein
Trichomonas vaginalis TVAG_310210   conserved hypothetical protein

Essentiality

TVAG_483890 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.14470 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.10.14470 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.10.14470 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.10.14470 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
TGME49_215195 Toxoplasma gondii Probably non-essential sidik
TGME49_215185 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TVAG_483890 (Trichomonas vaginalis), conserved hypothetical protein
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